C library for high-throughput sequencing data formats
HTSlib is an implementation of a unified C library for accessing common file formats, such as SAM, CRAM and VCF, used for high-throughput sequencing data, and is the core library used by samtools and bcftools.
HTSlib implements a generalized BAM index, with file extension .csi (coordinate-sorted index). The HTSlib file reader first looks for the new index and then for the old if the new index is absent.
This project also includes the popular tabix indexer, which indexes both .tbi and .csi formats, and the bgzip compression utility.
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Source Files
Filename | Size | Changed |
---|---|---|
baselibs.conf | 0000000098 98 Bytes | |
htslib-1.9.tar.bz2 | 0001178859 1.12 MB | |
libhts.changes | 0000009991 9.76 KB | |
libhts.spec | 0000005627 5.5 KB |
Revision 5 (latest revision is 18)
Pierre Bonamy (flyos)
accepted
request 633580
from
Pierre Bonamy (flyos)
(revision 5)
- Update to 1.9 * If `./configure` fails, `make` will stop working until either configure is re-run successfully, or `make distclean` is used. This makes configuration failures more obvious. (#711, thanks to John Marshall) * The default SAM version has been changed to 1.6. This is in line with the latest version specification and indicates that HTSlib supports the CG tag used to store long CIGAR data in BAM format. * bgzip integrity check option '--test' (#682, thanks to @sd4B75bJ, @jrayner) * Faidx can now index fastq files as well as fasta. The fastq index adds an extra column to the `.fai` index which gives the offset to the quality values. New interfaces have been added to `htslib/faidx.h` to read the fastq index and retrieve the quality values. It is possible to open a fastq index as if fasta (only sequences will be returned), but not the other way round. (#701) * New API interfaces to add or update integer, float and array aux tags. (#694) * Add `level=<number>` option to `hts_set_opt()` to allow the compression level to be set. Setting `level=0` enables uncompressed output. (#715) * Improved bgzip error reporting. * Better error reporting when CRAM reference files can't be opened. (#706) * Fixes to make tests work properly on Windows/MinGW - mainly to handle line ending differences. (#716) * Efficiency improvements: - Small speed-up for CRAM indexing. - Reduce the number of unnecessary wake-ups in the thread pool. (#703) - Avoid some memory copies when writing data, notably for uncompressed BGZF output. (#703) * Bug fixes: - Fix multi-region iterator bugs on CRAM files. (#684) - Fixed multi-region iterator bug that caused some reads to be skipped incorrectly when reading BAM files. (#687) - Fixed synced_bcf_reader() bug when reading contigs multiple times. (#691, reported by @freeseek) - Fixed bug where bcf_hdr_set_samples() did not update the sample dictionary when removing samples. (#692, reported by @freeseek) - Fixed bug where the VCF record ref length was calculated incorrectly if an INFO END tag was present. (71b00a) - Fixed warnings found when compiling with gcc 8.1.0. (#700) - sam_hdr_read() and sam_hdr_write() will now return an error code if passed a NULL file pointer, instead of crashing. - Fixed possible negative array look-up in sam_parse1() that somehow escaped previous fuzz testing. (#731, reported by @fCorleone) - Fixed bug where cram range queries could incorrectly report an error when using multiple threads. (#734, reported by Brent Pedersen) - Fixed very rare rANS normalisation bug that could cause an assertion failure when writing CRAM files. (#739, reported by @carsonhh)
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